Distance Between Houston and Cape Girardeau = Miles
Calculated driving distance between Houston, Texas and Cape Girardeau, Missouri is miles, this equals kilometres. Estimated driving time is in current traffic conditions. With an average car, this trip would cost around $ in gasoline, since you would need about gallons of fuel.(Based on current US Gas prices and average mileage of 3.6 gallons gas per mile).
Leaving from Houston, Texas located in Texas - United States you would reach Cape Girardeau, Missouri (Missouri - United States) in about driving an average speed of miles per hour to cover the miles, assuming traffic conditions stay unchanged and you don't take any breaks.
The map overview below shows the best driving route from Houston, Texas to Cape Girardeau, Missouri as a blue line on the map, with starting point (Houston) marked A, and destination point (Cape Girardeau) marked B. You can zoom in on the map to view road numbers, street names and other details both in Houston, Texas and Cape Girardeau, Missouri as well as every other town near or on your route.